- Homocystinuria in an Adulthood Presenting as Intracranial Thrombosis
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Jooyeon Song, Euihyun Kim, Inhee Kwak, Byung-Chul Lee, Mi Sun Oh
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Published online December 31, 2020
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- 뇌정맥혈전증으로 발현된 성인 호모시스틴뇨증
- 한국인구집단에서 편두통환자의 냄새공포증과 편두통 대체진단기준의 타당도 평가
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Yeo Jin Kim, Soo-Jin Cho, Byung-Kun Kim, Kwang-Soo Lee, Byung-Chul Lee, Min Kyung Chu
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Korean J Headache. 2011;12(2):91-96. Published online December 31, 2011
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- Objective: Osmophobia, intolerance to smell, is often reported by migraine patients during headache attack and is included as an item of alternative diagnostic criteria for migraine in the appendix of ICHD-2. Most of previous reports on osmo- phobia were hospital-based studies and osmphobia of migraineurs across population sample was not reported yet. The aims of this study are to assess osmophobia in migraineurs across Korean populationand to assess validity of alternative diagnostic criteria of migraine. Methods: We used data of Korean Headache Survey(KHS), a population-based study by a stratified random sampling in Korean population over age 19, and totally 1,507 were evaluated. Demographic profile, headache characteristics and impact of headache were assessed with a 12-item semi-structured interview. Headache type was identified according to ICHD-2. We assessed osmophobia by a question ‘Do you feel changes in your sense of smell during headache?(stronger or differently)’. Results: Prevalence for migraine was 6.1%. 50.5% of migraineurs reported osmophobia during migraine attack. Mig- raineurs with osmophobia had more headache aggravation by routine physical activity, phonophobia and higher HIT-6 score than migraineurs without osmophobia. There were no significant difference in unilaterality of pain, pain intensity in VAS score, pulsating quality and photophobia between migraineurs with osmophobia and migraineurs without osmo- phobia. The sensitivity of alternative criteria was 0.95[95% confidence interval(CI), 0.87-0.98] and specificity was 0.99(95% CI, 0.98-0.99). Conclusions: Approximately half of migraineurs across Korean population sample reported osmophobia. Alternative criteria showed good specificity and sensitivity.
- 심도의 편두통관련 장애와 관계된 인자
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Hye-Lim Kim, Mi-Sun Oh, Kyung-Ho Yu, Hyeo-Il Ma, Joo-Yong Kim, Byung-Chul Lee, Min-Kyung Chu
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Korean J Headache. 2011;12(1):49-56. Published online June 30, 2011
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Migraine is a heterogeneous condition that results in a spectrum of disability among individuals. Under- standing factors associated with severe disability of migraine is an important step towards optimizing interventions. Objective: To describe factors associated with severe migraine-related disability. Methods: We assessed factors of severe disability in univariate and multivariate analyses. Multivariate analyses were adjusted for demographic factors, clinical features, headache severity and frequency. Results: One hundred and ninety migraine patients were enrolled in this study. In the unadjusted univariate analyses, severe pain was associated with severe disability compared to mild pain. Aggravation by routing physical activity, pho- tophobia, visual aura and eyeball pain were associated with severe disability of migraine. Taking less than 4 headache days per month as the reference, ≥15 headache days per month was associated with severe disability. In the adjusted multivariate analyses, aggravation by routine physical activity, visual aura and ≥15 headache days per month were associated with severe migraine-related disability. Conclusions: These results demonstrated that a significant proportion of migraine sufferers had severe disability and there are specific factors associated with severe disability.
- 한국인 두통 환자에서 두통 발작 시 냄새공포증과 무전조편두통 대체 진단기준의 타당도 평가
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Ji-Young Kim, Min-Kyung Chu, Kyung-Ho Yu, Hyeo-Il Ma, Yun Joong Kim, Joo-Yong Kim, Byung-Chul Lee
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Korean J Headache. 2007;8(2):92-96. Published online December 31, 2007
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Sensory system may be activated during migraine attacks. Visual and auditory system activation have been addressed and implicated as an item of ICHD-II migraine diagnostic criteria. Recently the activation of olfactory systems during migraine attack has been occasionally commented. The object of this study is to assess osmophobia and validation of alternative diagnostic criteria of migraine without aura in Korean headache patients Methods: One hundred eighteen headache patients who visited outpatient clinic from August 2007 to October 2007, were evaluated for characteristics and associated features of headache such as frequency, duration, location, quality of pain, nausea, vomiting, photophobia, phonophobia and osmophobia. Osmophobia was classified as hyperosmia, hyposmia and dysosmia. Results: Eighty patients(67.8%) were diagnosed as having migraine and twenty four patients(20.3%) were diagnosed as having tension-type headache according to ICHD-II. Six patients were diagnosed as having probable migraine, two patients were diagnosed as having probable tension-type headache, two patients were diagnosed as having cluster headache and four patients were diagnosed as other primary headache. Thirty one patients complained of osmophobia during headache(90.3% very frequently and 9.7% frequently). Thirteen of them reported hypersomia (41.9%), seventeen reported dysosmia(54.8%) and one reported hyposmia(3.3%). All patients who complained of osmophobia during headache attacks were migraneurs. According to alternative diagnostic criteria of migraine without aura, 61 patients were diagnosed as having migraine without aura. Sensitivity of alternative diagnostic criteria was 0.85(95% CI, 0.74- 0.91) and specificity was 1.00(95% CI, 0.93-1.00). Conclusions: Osmophobia was observed in around 40% of migraineurs and was specific to migraine. Alternative dia- gnostic criteria of migraine without aura may be a valid method of classification.
- 일반연제-Trigeminal Neuralgia After Linear Pontine Trigeminal Root Lesion
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Seok-Beom Kwon, Sung-Hee Yun, Hee-Jung Suh, San-Jung, Sung-Hee Hwang , Byung-Chul Lee
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Korean J Headache. 2005;6(1):105-105. Published online June 30, 2005
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- Background
Various lesions affecting the trigeminal nerve entry zone may produce trigeminal neuralgia, and include tortuous vessels, aneurysms, arteriovenous malformations, and tumors. However, pontine in- farction or pontine multiple sclerosis(MS) lesion has not been well recognized as a cause of trigeminal neuralgia. Here we report two patients with a pontine lesion(ischemic or demyelinating) transecting the trigeminal pathways resulting with trigeminal neuralgia. These are very rare cases of unusual causes of trigeminal neuralgia. Case: A 55-year-old man presented with severe lacinating pain in the right V2 and V3 distributions. Magnetic resonance imaging of the brain demonstrated a small linear infarct at the root entry zone of the right trigeminal nerve in the pons. The other 30-year-old woman developed electric shocklike pain in the same distributions as a symptom of MS. Brain MRI showed multiple patchy cerebral lesions including right lateral portion of the pons. Conclusion: The mechanism for the trigeminal neuralgia due to pontine lesion may be increased neuronal activity in the trigeminal fascicles and nucleus. Our patients illustrate that the differential diag- nosis of trigeminal neuralgia should include pontine infarction or pontine MS lesion.
- 일반연제-Restless Leg Syndrome in Migraineurs- Hallym University Migraine in Nurses Study -
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Min-Kyung Chu, Kyung-Ho Yu, Hyeo-Il Ma, Yoon Kim, Joo-Yong Kim, Su-Jin Cho, Cheol-Ho Kim, Hong-Ki Song , Byung-Chul Lee
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Korean J Headache. 2005;6(1):104-104. Published online June 30, 2005
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and Objectives: Restless leg syndrome(RLS) is a prevalent disease which is often mis- diagnosed or underdiagnosed. RLS and migraine share some clinical features such as depression, sleep disorders, hemodialysis and positive family history of the disease. We analyzed the data of Hallym uni- versity migraine in nurses study to identify the association of RLS and migraine. Method: All 1501 nurses working at Hallym Medical Center were asked 72-item questionnaire on migraine including general information, occupational environments and characteristics, characteristics of headache, triggering factors, management of headache and migraine related disabilities. The diagnosis of RLS was made according to 3-item question set which was incorporated in the above questionnaire. The completed questionnaires were analyzed for the association of RLS and migraine. Results: 1341(89.3%) participants completed the questionnaire. All were female with mean age of 27.5±5.7. Based on ICHD-II, 276(17.5%) had migraine. Among migraineurs, 57(20.6%) have aura. 23(1.7%) had RLS and 9(39.1%) of them had migraine. The prevalence of RLS was significantly higher among migraineurs(3.4%) than non-migraineurs(1.3%). Migraineurs with RLS had tendency to have more aura than migraineurs without RLS. There was no significant difference in attack frequency, headache severity and MIDAS scores between migraineurs with RLS and migraineurs without RLS. Conclusion: There was significantly higher prevalence of RLS among migraineurs. Migraine with RLS showed tendency to have more aura.
- 간호사들의 월경관련 편두통 - 한림대학교 간호사 편두통 연구 -
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Min-Kyung Chu, Kyung-Ho Yu, Hyeo-Il Ma, Yoon Kim, Joo-Yong Kim, Su-Jin Cho, Cheol-Ho Kim, Byung-Chul Lee
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Korean J Headache. 2005;6(1):74-81. Published online June 30, 2005
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& Objectives: It is known that migraines in women are associated with menstruation. We analyzed the data of Hallym university migraine in nurses study to identify the prevalence and clinical features of menstruation related migraine in Korean nurses. Method: All 1501 nurses working at Hallym Medical Center were asked 72-item questionnaire on mig- raine including general information, occupational environments and characteristics, characteristics of headache, triggering factors, management of headache and migraine related disabilities. We categorized participants as having menstrually associated migrtaine(MAM) who answered that migraine attacks were associated to menstruation. Results: 89.2% of participants completed the questionnaire. All were female with mean age of 27.5±5.7, 276(17.5%) were classified as having migraine. 59(25.0%) of migraineurs had MAM. 36(61.0%) had migraine attacks in premenstrual period, 13(22.0%) in menstruation period, 1(1.7%) in postmenstrual period. 9(15.3%) of migraineurs reported varying relationship between migraine attacks and menstruation. Headache aggravation by routine physical activity was more common in MAM than non-MAM. There were no signi- ficant difference in attack frequency, headache severity and MIDAS scores between MAM and non-MAM. Conclusion: 25.0% of nurses with migraine had MAM. Migraine attacks occurring in premenstrual period was the most common form of MAM. MAM showed some different clinical features from those of non-MAM. Korean Journal of Headache 6(1):74-81, 2005
- 10대 편두통 환자에서 발생한 모자이크양상의 일과성 흑암시
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Min-Kyung Chu, Young-Hoon Yoon, Hee-Chan Choi, Kyung-Ho Yu, Woo-Kyung Kim, Hong-Ki Song, Byung-Chul Lee, Ju-Hun Lee
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Korean J Headache. 2004;5(2):148-152. Published online December 31, 2004
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- Transient monocular blindness(amaurosis fugax) is uncommon in young people and its mechanism is rarely demonstrated. We report a case of young patient with recurrent amaurosis fugax of mosaic pattern. A 18 year-old female migraineur experienced recurrent episodes of monocular blindness of her left eye, which clustered over 3 weeks. The episodes lasted for 3 to 10 minutes and were not associated with head- ache. She reported that visual loss began as several dark spots scattered on the visual field which enlar- ged slowly over one to three minutes and eventually coalesced, resulting complete blindness in affected eye. After a few minutes, the vision returned in a reverse pattern; patches of vision eventually enlarging to full field. Intracranial and extracranial cerebral arteries were normal on magnetic resonance angiography. After propranolol medication, the attack was no longer observed. Amaurosis fugax in young people have different patterns of visual loss from those in elderly. The mosaic pattern of transient monocular blind- ness in young people suggested a migraine variant with benign prognosis. Korean Journal of Headache 5(2):148-152, 2004
- Effects of Shift Working on Migraine - Hallym Medical Center Nurse Study -
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Min-Kyung Chu, Kyung-Ho Yu, Hyeo-Il Ma, Yoon-Jung Kim, Joo-Yong Kim, Hong- Ki Song, Byung-Chul Lee
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Korean J Headache. 2004;5(1):107-107. Published online June 30, 2004
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It is well known that migraine is related to sleep. Shift working was also reported as a triggering factor of migraine. The impact of shift working on migraine prevalence, frequency, and migraine related quality of life were not studied yet. The purposes of our study is to elucidate the relationship between shift working with migraine prevalence, attack frequency and migraine related quality of life. Method: All 401 nurses working at Hallym University Sacred Heart hospital were asked a 72-item questionnaire concerning migraine prevalence, attack frequency, migraine disability assessment(MIDAS), and Epworth sleepiness scale(ESS). The returned questionnaire was analyzed on the basis of the existence of shift working(SW). Result: Three hundreds seventy two nurses completed and returned the questionnaire for a response rate of 93.0%. According to International Headache Society criteria, 18.8% of the responding nurses were classified as having migraine. 285 of them were SW nurses. 58 of the SW nurses have migraine. 65.6% of the SW nurses with migraine answered that migraine was related to SW and night working was the most common working time related to migraine. Migraine prevalence, attack frequency, and MIDAS scores were not significantly different between SW and non-shift working(NoSW) nurses. ESS score was significantly higher in SW nurses than NoSW nurses. In NoSW nurses, sleepiness was related to migraine prevalence. However, sleepiness was not related to migraine prevalence in SW nurses. Conclusion: Even though many nurses believed that SW was a triggering factor for migraine attack, there were no significant differences in migraine prevalence, attack frequency, and migraine related quality of life between SW and NoSW nurses. Sleepiness was related to migraine prevalence in NoSW nurses. Revealing the relationship between migraine and SW would help for both unveiling the nature of disease and the effective management of migraine. Korean Journal of Headache 5(1):107-107, 2004
- 주야 교대 근무가 편두통에 미치는 영향 - 한림대학교 의료원 간호사 연구 -
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Min-Kyung Chu, Kyung-Ho Yu, Hyeo-Il Ma, Yoon-Jung Kim, Joo-Yong Kim, Hong- Ki Song, Byung-Chul Lee
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Korean J Headache. 2004;5(1):83-89. Published online June 30, 2004
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It is well known that migraine is related to sleep. Shift working was also reported as a triggering factor of migraine. The impact of shift working on migraine prevalence, frequency, and migraine related quality of life were not studied yet. The purposes of our study is to elucidate the relationship between shift working with migraine prevalence, attack frequency and migraine related quality of life. Method: All 401 nurses working at Hallym University Sacred Heart hospital were asked a 72-item questionnaire concerning migraine prevalence, attack frequency, migraine disability assessment(MIDAS), and Epworth sleepiness scale(ESS). The returned questionnaire was analyzed on the basis of the existence of shift working(SW). Result: Three hundreds seventy two nurses completed and returned the questionnaire for a response rate of 93.0%. According to International Headache Society criteria, 18.8% of the responding nurses were classified as having migraine. 285 of them were SW nurses. 58 of the SW nurses have migraine. 65.6% of the SW nurses with migraine answered that migraine was related to SW and night working was the most common working time related to migraine. Migraine prevalence, attack frequency, and MIDAS scores were not significantly different between SW and non-shift working(NoSW) nurses. ESS score was significantly higher in SW nurses than NoSW nurses. In NoSW nurses, sleepiness was related to migraine prevalence. However, sleepiness was not related to migraine prevalence in SW nurses. Conclusion: Even though many nurses believed that SW was a triggering factor for migraine attack, there were no significant differences in migraine prevalence, attack frequency, and migraine related quality of life between SW and NoSW nurses. Sleepiness was related to migraine prevalence in NoSW nurses. Revealing the relationship between migraine and SW would help for both unveiling the nature of disease and the effective management of migraine. Korean Journal of Headache 5(1):83-89, 2004
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